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Figure 7 | Journal of Inflammation

Figure 7

From: CCR2 and CXCR4 regulate peripheral blood monocyte pharmacodynamics and link to efficacy in experimental autoimmune encephalomyelitis

Figure 7

Chronic MK0812 treatment inhibits EAE accompanied by pharmacodynamic effects. A, Effect of MK0812 (10 mg/kg, b.i.d., p.o.) and FTY720 (1 mg/kg. q.d., p.o.) on EAE severity in C57BL/6J mice. Drug dosing was initiated at d5 after immunization with MOG35-55 peptide in CFA. B, The areas under the curve from the data depicted in (A) were calculated. C, Blood CD11b+Ly6Chi monocyte numbers (C) and the plasma concentration of CCL2 (D) were determined from the mice at d21. ***p < 0.001, **p < 0.01, *p < 0.05 compared to MC group. The data presented are the mean ± S.E.M. of twnenty-five mice per group and are representative of three independent experiments.

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