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Table 4 Effects of GF10903X (1 μM) on the IP3 concentrations of chemoattractant-activated neutrophils.

From: Protein kinase C promotes restoration of calcium homeostasis to platelet activating factor-stimulated human neutrophils by inhibition of phospholipase C

System

IP3 concentrations (pg/ml) measured at:

 

10 sec

20 sec

PAF (20 nM)

46 ± 3.5

N.D.

GF10903X + PAF (20 nM)

75 ± 5.5*

N.D.

PAF (200 nM)

82 ± 8.3

65 ± 17

GF10903X + PAF (200 nM)

136 ± 6.4*

120 ± 2.3*

FMLP (1 μM)

58 ± 16

N.D.

GF10903X + FMLP

96 ± 8*

N.D.

  1. The results of 4 experiments are expressed as the mean IP3 concentration ± S.E.M., rising from basal values of 35 ± 2 pg/ml, for PAF (20 and 200 nM) or FMLP (1 μM)- treated cells, in the absence or presence of GF10903X. * P < 0.05 for comparison with the untreated system.