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Table 4 Effects of GF10903X (1 μM) on the IP3 concentrations of chemoattractant-activated neutrophils.

From: Protein kinase C promotes restoration of calcium homeostasis to platelet activating factor-stimulated human neutrophils by inhibition of phospholipase C

System IP3 concentrations (pg/ml) measured at:
  10 sec 20 sec
PAF (20 nM) 46 ± 3.5 N.D.
GF10903X + PAF (20 nM) 75 ± 5.5* N.D.
PAF (200 nM) 82 ± 8.3 65 ± 17
GF10903X + PAF (200 nM) 136 ± 6.4* 120 ± 2.3*
FMLP (1 μM) 58 ± 16 N.D.
GF10903X + FMLP 96 ± 8* N.D.
  1. The results of 4 experiments are expressed as the mean IP3 concentration ± S.E.M., rising from basal values of 35 ± 2 pg/ml, for PAF (20 and 200 nM) or FMLP (1 μM)- treated cells, in the absence or presence of GF10903X. * P < 0.05 for comparison with the untreated system.