System | Peak (nM) | Plateau (min) | Magnitude of decrement (nM) from peak measured at: | |
---|---|---|---|---|
1 min | 2 min | |||
PAF (20 nM) Control (n = 6) | 278 ± 16 | 0.4 ± 0.05 | 108 ± 10 | 168 ± 12 |
Staurosporine (400 nM) (n = 4) | 290 ± 8 | 1.0 ± 0.05* | 52 ± 4* | 160 ± 15 |
GF10903X (0.5 μM) (n = 7) | 258 ± 4 | 1.0 ± 0.04* | 32 ± 2* | 124 ± 5* |
GF10903X (1 μM) (n = 7) | 266 ± 10 | 1.1 ± 0.02* | 24 ± 3* | 104 ± 4* |
Rolipram (2 μM) (n = 4) | 274 ± 4 | 0.13 ± 0.03 | 188 ± 4 | 216 ± 4 |
Staurosporine + Rolipram (n = 4) | 286 ± 6 | 0.2 ± 0.06 | 144 ± 8** | 200 ± 8 |
GF10903X (0.5 μM) + Rolipram (n = 4) | 286 ± 7 | 0.17 ± 0.03 | 164 ± 14** | 196 ± 10** |
GF10903X (1 μM) + Rolipram (n = 4) | 282 ± 8 | 0.27 ± 0.03 | 152 ± 18** | 200 ± 11** |
FMLP (1 μM) Control (n = 6) | 285 ± 7 | 0.1 ± 0.01 | 94 ± 3 | 142 ± 9 |
GF10903X (1 μM) (n = 11) | 278 ± 4 | 0.53 ± 0.05* | 54 ± 3* | 107 ± 5* |