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Table 1 Antibody Array analysis of changes in cytokine levels in mesangial cells following exposure to DL-homocysteine (50 μM).

From: Homocysteine-induced macrophage inflammatory protein-2 production by glomerular mesangial cells is mediated by PI3 Kinase and p38 MAPK

Cytokine Change P-value
TIMP-1 1.9 0.02
TNFα 1.1 NS
β-NGF 1.1 NS
MIP-3α 1 NS
MCP-1 1.2 NS
IL-6 1.1 NS
IL-10 1.1 NS
CINC-2 (MIP-2) 2.4 0.01
IFN-γ 0.5 0.045
Fractalkine 0.2 0.02
GM-CSF 0.4 0.048
LIX 0.9 NS
  1. Values are expression relative to levels in cells cultured in glucose (5.6 mM) with 100 μM L-cysteine but lacking homocysteine; n = 3. Abbreviations: TIMP-1 - tissue inhibitor of metalloproteinases 1; TNFα- tumor necrosis factor alpha; β-NGF - beta nerve growth factor, MIP-3α- macrophage inflammatory protein 3 alpha; MCP-1 - monocyte chemotactic protein 1; IL-6 - interleukin 6; IL-10 - interleukin 10; CINC-2 - cytokine-induced neutrophil chemoattractant 2 (also known as macrophage inflammatory protein 2 and GROβ [growth-regulated gene product beta]); IFN-γ - interferon beta; GM-CSF - granulocyte monocyte colony stimulating factor; LIX - Lipopolysaccharide (LPS)-induced chemokine.