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Figure 1 | Journal of Inflammation

Figure 1

From: CCR5 signalling, but not DARC or D6 regulatory, chemokine receptors are targeted by herpesvirus U83A chemokine which delays receptor internalisation via diversion to a caveolin-linked pathway

Figure 1

Competitive binding of U83A to signalling receptors CCR1 and CCR5 displaces human chemokines. COS-7 cells transfected with CCR1 (A) or CCR5 (B, C) were incubated with [125I]CCL3 (A and B) or [125I]CCL5 (C) in the presence of increasing concentration of cold chemokine. IC50 obtained were for (A) U83A: 0.4 nM, (B) U83A: 0.01 nM and (C) U83A-N: 0.1 nM. Binding curves were fitted by nonlinear regression and IC50 values were calculated using Graphpad Prism.

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Journal of Inflammation

ISSN: 1476-9255

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