Figure 4

Effect of calpain inhibitors on COX-2 protein. PIN1 KD and Control shRNA MAEC were treated with vehicle (DMSO) or 25 μM zVF (A) or different concentrations of PD150606 (B), and then with LPS and IFN for 24 h. Representative western blots of COX-2 and α-tubulin are shown. Bars represent mean + SE ratio of COX-2 to α-tubulin from densitometric analysis of images from 3 independent cultures in each group. *: p < 0.05 for comparison between vehicle and zVF, and +, p < 0.05 for comparison between KD and Control shRNA.