Figure 7From: Terameprocol, a methylated derivative of nordihydroguaiaretic acid, inhibits production of prostaglandins and several key inflammatory cytokines and chemokinesThe effects of TMP on cytokine, chemokine and inflammatory lipid production by peritoneal macrophages. Macrophages were collected from C57BL6/J mice and left either untreated (Media), or treated overnight with 1 μg/ml LPS and/or 25 μM TMP. Levels of PGE2 (A), TNF-α (B), MCP-1 (C) and IL-12/23 p40 (D) in cell culture supernatants were subsequently determined by ELISA. Panels show means ± SEM from 2–3 experiments for each mediator. Asterisks indicate significant differences between treatments with LPS and LPS/TMP (p < 0.05, Student's t-test).Back to article page