Table 1 Roles of selected transcription factors in vascular inflammation and aging
From: Alterations in transcriptional responses associated with vascular aging
Transcription Factors | Pro-/Anti-inflammatory | Selected Target Genes | Alterations with Aging |
|---|---|---|---|
NF-κB | Pro-inflammatory | MCP-1, ICAM-1, NOS2 | Increased |
HIF-1α | Anti-inflammatory | VEGF, SDF-1 | Decreased |
Ets-1 | Pro-inflammation | MCP-1, VCAM-1, PDGF, p16INK4a | Increased |
ERG | Anti-inflammatory | VWF, VE-Cad, Ang2, IL-8 | Unknown |
PPAR-α, -γ | Pro-inflammatory | NF-|B, pro-inflammatory cytokines, NOS2, VCAM-1 | Decreased |