Figure 3
From: Cyclic GMP protects human macrophages against peroxynitrite-induced apoptosis
GEA-3162 induces apoptosis in human MDMϕ. A – representative flow cytometry plots. B – induction of apoptosis by GEA-3162 but not DETA/NO. **P < 0.01 significantly greater annexin V binding compared to control; #P < 0.05 significantly greater PI staining compared to control (unpaired, one-way ANOVA followed by post hoc Dunnett's test; n = 6 – 9). C – apoptosis (annexin V binding; left panel) induced by GEA-3162 was elevated by SOD (500 U.ml-1). A combination of SOD and catalase (both 500 U.ml-1) blunted the SOD-induced elevation of apoptosis but not reduce GEA-3162-induced apoptosis. PI staining (right panel) was unaffected by SOD or catalase. **P < 0.01; matched two ANOVA followed by post hoc Bonferroni's test; n = 6.