Figure 2
From: Inhibition of zymosan-induced kidney dysfunction by tyrphostin AG-490
Effect of AG-490 on kidney dysfunction induced by zymosan. A, The drug inhibited the plasma level of creatinine. B, AG-490 prevented the development of proteinuria. The data represent the mean ± SD from 3 independent experiments including 5 mice/group; **p < 0.01 and ***p < 0.001 versus zymosan-injected group; Student's t test. C-E, Histological evaluation of kidneys. The representative data from 2 experiments (n = 5/group) showed glomerular lesions (indicated with arrows on Ca; 1 × 400), massive cell infiltration in renal medulla (indicated with arrows on Da, 1 × 400) and tubular necrosis (indicated with arrows on Ea; 1 × 400) in shock mice (ZY) on day 21 of zymosan injection. The described pathology was not found in AG-490-treated mice (Cb, Db, Eb; ZY+AG-490).