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Table 3 Inflammatory Parameters of Arthritis Scoring System

From: Evaluation of anti-IL-6 monoclonal antibody therapy using murine type II collagen-induced arthritis

Inflammatory Parameter

Score

Observation marker

Synovitis (judged by the thickness of the synovial membrane)

0

less than 3 cells thick

 

1

3 – 5 cells thick

 

2

6 – 10 cells thick

 

3

10 – 20 cells thick

 

4

20 – 30 cells thick

 

5

Beyond 30 cells thick

Pannus formation

0

No pannus formation

 

1

Microvillus present

 

2

Clear pannus attachment

 

3

Marked pannus attachment

 

4

Joint space filled by pannus

 

5

Extensive pannus proliferation

Marginal erosions

0

No erosions visible

 

1

Minor indentation in area of capsular attachment

 

2

Clear erosions of cartilage

 

3

Erosions extend into subchondral bone

 

4

Major erosion of bone and cartilage

 

5

Loss of visible cartilage and major bone loss

Architectural changes

0

Normal joint architecture

 

1

Edematous changes

 

2

Minor subluxation of articulating surfaces

 

3

Major subluxation of articulating surfaces

 

4

Loss of joint landmarks

 

5

Complete fibrosis and collagen bridging

Overall score

0

Classical normal joint appearance

 

1

Minor changes; consistent with remission; may be clinically normal.

 

2

Moderate inflammatory disease

 

3

Major inflammatory disease

 

4

Destructive, erosive arthritis

 

5

Destructive, erosive arthritis with major bone remodeling.