From: Evaluation of anti-IL-6 monoclonal antibody therapy using murine type II collagen-induced arthritis
Inflammatory Parameter | Score | Observation marker |
---|---|---|
Synovitis (judged by the thickness of the synovial membrane) | 0 | less than 3 cells thick |
 | 1 | 3 – 5 cells thick |
 | 2 | 6 – 10 cells thick |
 | 3 | 10 – 20 cells thick |
 | 4 | 20 – 30 cells thick |
 | 5 | Beyond 30 cells thick |
Pannus formation | 0 | No pannus formation |
 | 1 | Microvillus present |
 | 2 | Clear pannus attachment |
 | 3 | Marked pannus attachment |
 | 4 | Joint space filled by pannus |
 | 5 | Extensive pannus proliferation |
Marginal erosions | 0 | No erosions visible |
 | 1 | Minor indentation in area of capsular attachment |
 | 2 | Clear erosions of cartilage |
 | 3 | Erosions extend into subchondral bone |
 | 4 | Major erosion of bone and cartilage |
 | 5 | Loss of visible cartilage and major bone loss |
Architectural changes | 0 | Normal joint architecture |
 | 1 | Edematous changes |
 | 2 | Minor subluxation of articulating surfaces |
 | 3 | Major subluxation of articulating surfaces |
 | 4 | Loss of joint landmarks |
 | 5 | Complete fibrosis and collagen bridging |
Overall score | 0 | Classical normal joint appearance |
 | 1 | Minor changes; consistent with remission; may be clinically normal. |
 | 2 | Moderate inflammatory disease |
 | 3 | Major inflammatory disease |
 | 4 | Destructive, erosive arthritis |
 | 5 | Destructive, erosive arthritis with major bone remodeling. |