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Table 3 Inflammatory Parameters of Arthritis Scoring System

From: Evaluation of anti-IL-6 monoclonal antibody therapy using murine type II collagen-induced arthritis

Inflammatory Parameter Score Observation marker
Synovitis (judged by the thickness of the synovial membrane) 0 less than 3 cells thick
  1 3 – 5 cells thick
  2 6 – 10 cells thick
  3 10 – 20 cells thick
  4 20 – 30 cells thick
  5 Beyond 30 cells thick
Pannus formation 0 No pannus formation
  1 Microvillus present
  2 Clear pannus attachment
  3 Marked pannus attachment
  4 Joint space filled by pannus
  5 Extensive pannus proliferation
Marginal erosions 0 No erosions visible
  1 Minor indentation in area of capsular attachment
  2 Clear erosions of cartilage
  3 Erosions extend into subchondral bone
  4 Major erosion of bone and cartilage
  5 Loss of visible cartilage and major bone loss
Architectural changes 0 Normal joint architecture
  1 Edematous changes
  2 Minor subluxation of articulating surfaces
  3 Major subluxation of articulating surfaces
  4 Loss of joint landmarks
  5 Complete fibrosis and collagen bridging
Overall score 0 Classical normal joint appearance
  1 Minor changes; consistent with remission; may be clinically normal.
  2 Moderate inflammatory disease
  3 Major inflammatory disease
  4 Destructive, erosive arthritis
  5 Destructive, erosive arthritis with major bone remodeling.