Anti-IL-6 mAb inhibited SAA production in CIA. DBA/1 LacJ mice were dosed with anti-IL-6 antibody (1 mg or 5 mg/mouse) or irrelevant control antibody in the CIA model for 10 weeks. Serum samples were collected at final harvest and SAA levels were measured by ELISA. * p < 0.05 versus isotype control mAb-treated groups. Statistical differences between the groups were determined using ANOVA (SPSS Inc, Chicago, IL).