Figure 6

Anti-Il-6 treated mice had reduced synovitis and pannus scores. DBA/1 LacJ mice were dosed with anti-IL-6 antibody (1 mg or 5 mg/week) or irrelevant control antibody in CIA model for 10 weeks. Mice were sacrificed and joint specimens prepared for histopathological assessment as described in materials and methods. Specimen slides were evaluated using the scoring system from Table 3. Bars represent the mean (± SEM) of the inflammatory score for each parameter for all 4 paws of each mouse in the group. There was a significant difference (p < 0.005) between the control mAb and both anti-IL-6 mAb doses for both synovitis and pannus. Statistical differences between the groups were determined using ANOVA (SPSS Inc, Chicago, IL).