Figure 5From: Evaluation of anti-IL-6 monoclonal antibody therapy using murine type II collagen-induced arthritisAnti-IL-6 antibody reduced the inflammatory histopathology of CIA. DBA/1 LacJ mice were dosed with irrelevant control antibody (A) or anti-IL-6 antibody (1 mg/week (B) or 5 mg/week (C)) for 10 weeks. Mice were sacrificed and joint specimens prepared for histopathological assessment as described in materials and methods. Photomicrographs are 200×.Back to article page