Anti-IL-6 mAb inhibited TNFα and OPG expression in CIA. DBA/1 LacJ mice were dosed with anti-IL-6 antibody (5 mg/mouse) or irrelevant control antibody in the CIA model for 10 weeks. Paws were collected at final harvest and RNA was purified. cDNA was prepared and analyzed using real-time PCR. * p < 0.05 versus isotype control mAb-treated groups. Statistical differences between the groups were determined using ANOVA (SPSS Inc, Chicago, IL).