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Figure 4 | Journal of Inflammation

Figure 4

From: JNK pathway is involved in the inhibition of inflammatory target gene expression and NF-kappaB activation by melittin

Figure 4

JNK inhibitor suppressed the inhibitory effect of melittin and bee venom on the on NF-κB-dependent luciferase induced by LPS or SNP. Raw 264.7 cells (A) and THP-1 cells (B) were transfected with pNF-κB-Luc plasmid (5× NF-κB), Raw 264.7 cells or THP-1 cells were pretreated with 10 and 20 μM SP600125 1 hr prior to the treatment with melittin or bee venom with or without LPS (1 μg/ml) or SNP (200 μM) at 37°C for 2 hr, and then luciferase activities were determined. All values represent means ± S.E. of three independent experiments performed in triplicate.

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