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Figure 2 | Journal of Inflammation

Figure 2

From: Inhibition of oncogene-induced inflammatory chemokines using a farnesyltransferase inhibitor

Figure 2

Reduced expression of pro-inflammatory chemokines in FTI-treated thyrocytes. (A) mRNA expression of the pro-inflammatory chemokine Ccl2 in PC Cl3RP3 thyrocytes cultured with indicated concentrations of FTI for 24 hours. (B) mRNA expression of the pro-inflammatory chemokine Cxcl1 in PC Cl3RP3 thyrocytes cultured with indicated concentrations of FTI for 24 hours. For both chemokines investigated, significant reduction in gene expression is seen, even at nanomolar concentrations of FTI. Data are normalized to G3pdh expression within each sample. Error bars represent s.e.m. and are representative of three independent experiments performed in triplicate (n = 3). *p < 0.05, **p < 0.01.

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