Cellular and molecular mechanisms of cigarette smoke-induced lung damage and prevention by vitamin C

Journal of Inflammation

Table 1 Vitamin C levels in the lung tissues of vitamin C-restricted (1 mg/day) and vitamin C-supplemented (5 mg/day & 15 mg/day) guinea pigs before and after CS exposure

Days of CS exposure	Vitamin C supplemented Groups
	1 mg supplemented group		5 mg supplemented group		15 mg supplemented group
	Vitamin C level (mM)		Vitamin C level (mM)		Vitamin C level (mM)
	Before CS exposure	After CS exposure	Before CS exposure	After CS exposure	Before CS exposure	After CS exposure
7	0.31 ± 0.02*	0.10 ± 0.01	0.85 ± 0.08	0.30 ± 0.04	1.45 ± 0.13	1.31 ± 0.14
14	0.22 ± 0.02	0.10 ± 0.01	0.80 ± 0.08	0.28 ± 0.03	1.42 ± 0.13	1.30 ± 0.12
21	0.20 ± 0.02	0.10 ± 0.01	0.80 ± 0.08	0.28 ± 0.03	1.40 ± 0.13	1.28 ± 0.12

Dietary supplementation of vitamin C was initiated after deprivation of the vitamin for 7 days. After 7 days of deprivation, the vitamin C content of the lung was estimated to be 0.24 ± 0.02 mM SD (n = 4).
* Data represent ± S.D (n = 4). Vitamin C was measured by HPLC as described in Methods.

ISSN: 1476-9255