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Figure 1 | Journal of Inflammation

Figure 1

From: Cellular and molecular mechanisms of cigarette smoke-induced lung damage and prevention by vitamin C

Figure 1

Histopathology of lung sections of guinea pigs exposed to CS showing progressive lung damage and prevention by moderately large dosage of vitamin C. A, Histology of lung sections of guinea pigs fed 1 mg or 15 mg vitamin C; Air, sham controls exposed to air; CS, exposed to CS; stained by hematoxylin and eosin. The number of guinea pigs used in each group was 4. Eight images were analyzed in 4 lung sections (2 images/section/animal) from each group (magnification ×10). B, C, Morphometric Measurements of the number of alveolar air space and surface density (S/V). Values are ± S.D. S/V has been calculated by the formula S/V (surface density) = π/4 × P/A, where P is the mean perimeter (contour length) of air space and A is the area of air space [6]. The number of air spaces and the S/V values calculated after 7, 14 and 21 days of smoke exposure are significantly less (p < 0.05)than that observed after 1 day exposure; * over the bars (Fig. 1 C) indicate p < 0.05 with respect to controls.

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