Table 1 Circulatory and respiratory data from pigs during endotoxin infusion.
-60 (min) | 0 (min) | 60 (min) | 120 (min) | 210 (min) | 300 (min) | ||
|---|---|---|---|---|---|---|---|
group | mean ± sem | mean ± sem | mean ± sem | mean ± sem | mean ± sem | mean ± sem | |
HR | Control | 102 ± 7 | 90 ± 4 | 93 ± 6 | 96 ± 8 | 91 ± 8 a | 97 ± 8 b |
(bpm) | CO | 103 ± 4 | 94 ± 7 | 88 ± 4 | 79 ± 4 | 88 ± 5 | 92 ± 8 b |
MAP | Control | 101 ± 5 | 95 ± 4 | 88 ± 5 | 91 ± 8 | 93 ± 11 a | 95 ± 6 b |
(mmHg) | CO | 100 ± 4 | 89 ± 3 | 84 ± 5 | 94 ± 3 | 89 ± 7 | 86 ± 7 a |
CVP | Control | 3 ± 0.6 | 4 ± 0.6 | 7 ± 0.6 | 8 ± 0.8 | 8 ± 0.8 a | 6 ± 0.6 b |
(mmHg) | CO | 4 ± 0.7 | 4 ± 0.8 | 6 ± 0.8 | 7 ± 0.7 | 6 ± 0.7 | 7 ± 0.6 a |
Cardiac | Control | 5.0 ± 0.4 a | 4.8 ± 0.4 | 3.7 ± 0.4 | 4.1 ± 0.4 a | 2.9 ± 0.3 a | 3.5 ± 0.5 b |
output (l/min) | CO | 5.8 ± 0.3 | 5.2 ± 0.3 | 3.8 ± 0.2 a | 3.7 ± 0.3 | 2.9 ± 0.2 a | 3.0 ± 0.2 a |
P a CO 2 | Control | 4.5 ± 0.3 b | 5.0 ± 0.2 a | 5.3 ± 0.2 a | 5.8 ± 0.1 b | 5.9 ± 0.3 c | 5.9 ± 0.3 b |
(kPa) | CO | 4.5 ± 0.2 | 4.9 ± 0.1 | 5.4 ± 0.2 | 5.7 ± 0.2 | 6.0 ± 0.3 | 6.2 ± 0.9 a |
P a O 2 | Control | 19.3 ± 0.7 b | 18.3 ± 0.4 a | 29.2 ± 3.0 a | 28.3 ± 6.3 b | 25.0 ± 5.7 c | 19.4 ± 3.6 b |
(kPa) | CO | 20.4 ± 0.5 | 20.0 ± 0.7 | 38.2 ± 5.7 | 38.7 ± 5.8 | 22.8 ± 5.1 | 28.5 ± 5.8 a |
Hb | Control | 92 ± 1.9 a | 89 ± 1.5 | 95 ± 2.7 | 100 ± 2.2 | 108 ± 1.2 a | 103 ± 2.2 b |
(g/l) | CO | 93 ± 2.8 | 88 ± 2.1 | 91 ± 1.6 | 101 ± 1.8 | 108 ± 2.9 | 105 ± 3.5 a |
FiO 2 | Control | 30 ± 0 | 30 ± 0 | 55 ± 5.8 | 62 ± 8.0 | 68 ± 7.0 | 70 ± 6.6 |
(%) | CO | 30 ± 0 | 30 ± 0 | 56 ± 5.9 | 64 ± 8.4 | 78 ± 8.3 | 81 ± 7.5 |