Figure 3

Plasma cytokine concentrations in pigs after endotoxin-induced systemic inflammation with or without CO treatment. Values are presented as individual measurements for CO treated animals (open circles) and controls (closed circles). A dotted (CO group) and solid (controls) line represents means for the two groups (n = 10 except for the CO-group at 270 and 300 min where n = 9 and for controls at 150, 180 and 210 min where n = 9 and at 240, 270 and 300 min where n = 8). Endotoxin was administered (0.05 μg/kg/h) just after time 0, reaching maximum infusion rate (0.25 μg/kg/h) at 30 min. No significant differences were detected between the groups for any of the cytokines (TNF: ANOVA F(1, 8) = 1.074, IL-6: ANOVA F(1, 8) = 0.892, IL-10: ANOVA F(1, 8) = 1.347, IL-1beta: ANOVA F(1, 8) = 1.716).