A dynamic model of gene expression in monocytes reveals differences in immediate/early response genes between adult and neonatal cells

Lawrence, Shelley; Tang, Yuhong; Frank, M Barton; Dozmorov, Igor; Jiang, Kaiyu; Chen, Yanmin; Cadwell, Craig; Turner, Sean; Centola, Michael; Jarvis, James N

doi:10.1186/1476-9255-4-4

Table 1 Differentially expressed genes between adult and cord monocytes at specific time points. T = time (min) at which the sample was taken. Numbers indicate corrected expression values.

From: A dynamic model of gene expression in monocytes reveals differences in immediate/early response genes between adult and neonatal cells

				Adult	Adult	Adult	Cord	Cord
	Genbank #	Symbol	Gene Description	T = 0	t = 45	t = 120	t = 0	t = 45	t = 120
Apoptosis
	NM_033423	CTLA1	Similar to granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	317	419	299	199	193	264
	AB037796	PDCD6IP	Programmed cell death 6 interacting protein	75	155	68	79	70	81
	NM_024969	TAIP-2	TGFb-induced apoptosis protein 2	63	113	107	53	68	116
	NM_003127	SPTAN1	Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)	713	842	*1171*	724	824	*2093*
Protein synthesis, processing, degradation
	AK001313	RPLP0	Ribosomal protein, large, P0	704	1465	947	703	756	669
	NM_006799	PRSS21	Protease, serine, 21 (testisin)	204	789	457	169	360	400
	NM_003774	GALNT4	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4)	576	651	648	528	378	578
	AK057790		cDNA FLJ25061 fis, clone CBL04730	245	373	302	244	215	200
	NM_004223	UBE2L6	Ubiquitin-conjugating enzyme E2L 6	128	191	146	108	99	109
	NM_014710	GPRASP1	KIAA0443 gene product	122	182	106	113	119	95
	NM_021090	MTMR3	Myotubularin related protein 3	109	171	137	108	87	138
	AF339824	HS6ST3	Heparan sulfate 6-O-sulfotransferase 3	89	112	91	94	46	76
	NM_012180	FBXO8	F-box only protein 8	40	67	42	45	33	43
	U66589	RPL5	Ribosomal protein L5	34	48	37	30	26	36
	NM_001870	CPA3	Carboxypeptidase A3 (mast cell)	183	*495*	610	146	*949*	756
	NM_006145	DNAJB1	DnaJ (Hsp40) homolog, subfmaily B, member 1	179	277	*408*	168	299	*745*
	AK025547	MRPL30	Mitochondrial ribosomal protein L30	83	118	*126*	81	101	*211*
	NM_000439	PCSK1	Proprotein convertase subtilisin/kexin type 1	39	55	53	40	78	88
Cell/Organism Movement
	NM_002067	GNA11	Guanine nucleotide binding protein (G protein), alpha 11 (Gq class)	555	870	607	540	468	664
	NM_002465	MYBPC1	Myosin binding protein C, slow type	81	140	154	88	80	161
	NM_003275	TMOD	Tropomodulin	276	*151*	481	257	*344*	503
	AK026164	MYL6	Myosin, light polypeptide 6, alkali, smooth muscle and non-muscle	7	6	48	5	16	11
Small Molecule Interactions
	NM_006030	CACNA2D2	Calcium channel, voltage-dependent, alpha 2/delta subunit 2	670	1390	1021	641	639	946
	AK025170	SFXN5	FLJ21517 fis, clone COL05829	431	537	437	405	295	374
	NM_021097	SLC8A1	Solute carrier family 8 (sodium/calcium exchanger), member 1	396	456	458	412	276	369
Signal Transduction
	NM_032144	RAB6C	RAB6C	827	1658	1307	626	773	1251
	NM_001982	ERBB3	V-erb-b2 erythroblastic leukemia viral oncogene homolog 3	603	1375	671	555	584	643
	AK026479	SNX14	Sorting nexin 14	682	1207	879	624	567	883
	NM_018979	PRKWNK1	Protein kinase, lysine deficient 1	451	813	782	516	480	792
	NM_004811	LPXN	Leupaxin	329	539	445	323	298	503
	BC005365		clone IMAGE:3829438, mRNA, partial cds	257	418	275	275	275	206
	NM_004723	ARHGEF2	Rho/rac guanine nucleotide exchange factor (GEF) 2	215	300	228	197	176	186
	AF130093	MAP3K4	Mitogen-activated protein kinase kinase kinase 4	237	285	275	221	171	223
	AK000383	MKPX	Mitogen-activated protein kinase phosphatase x	218	221	244	233	126	197
	NM_022304	HRH2	Histamine receptor H2	45	121	86	42	74	79
	NM_030753	WNT3	Wingless-type MMTV integration site family member 3	105	117	92	109	63	81
	AB024574	GTPBP2	GTP binding protein 2	89	90	99	74	57	92
	NM_002836	PTPRA	Protein tyrosine phosphatase, receptor type, A	8	6	80	6	16	28
	NM_003656	CAMK1	Calcium/calmodulin-dependent protein kinase I	4940	10131	*4446*	4785	4907	*7190*
Cellular Metabolism & Cell Division
	NM_006170	NOL1	Nucleolar protein 1 (120 kD)	575	1815	1021	499	896	1093
	AL133115	COVA1	Cytosolic ovarian carcinoma antigen 1	1381	1294	848	1309	658	808
	D86962	GRB10	Growth factor receptor-bound protein 10	619	906	200	609	512	179
	NM_005628	SLC1A5	Solute carrier family 1 (neutral amino acid transporter), member 5	338	801	600	311	397	524
	D17525	MASP1	Mannan-binding lectin serine protease 1 (C4/C2 activating component of Ra-reactive factor)	372	654	43	361	325	55
	NM_016518	PIPOX	Pipecolic acid oxidase	240	545	330	221	293	286
	NM_012157	FBXL2	F-box and leucine-rich repeat protein 2	274	501	374	249	277	298
	NM_018446	AD-017	Glycosyltransferase AD-017	301	369	337	288	223	327
	NM_001609	ACADSB	Acyl-Coenzyme A dehydrogenase, short/branched chain	354	368	325	273	211	276
	NM_001647	APOD	Apolipoprotein D	259	358	289	261	202	205
	NM_012113	CA14	Carbonic anhydrase XIV	218	356	279	251	194	270
	AB067472	DKFZP434L1435	KIAA1885 protein	150	213	186	166	119	163
	NM_002916	RFC4	Replication factor C (activator 1) 4 (37 kD)	102	177	119	105	86	132
	NM_004889	ATP5J2	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit f, isoform 2	106	147	76	102	76	62
	AK057066		cDNA FLJ32504 fis, clone SMINT1000016, weakly similar to 2-hydroxyacylsphingosine 1b	69	121	126	64	75	84
	AK021722	AGPAT5	Lysophosphatidic acid acyltransferase, epsilon	37	71	48	42	39	46
	NM_003664	AP3B1	Adaptor-related protein complex 3, beta 1 subunit	34	52	29	37	24	30
	AF146760	Sept10	Septin 10	22	36	23	26	16	28
	NM_004910	PITPNM	Phosphatidylinositol transfer protein, membrane-associated	2611	*2809*	2410	2974	*4590*	2675
	NM_018216	FLJ10782	Pantothenic acid kinase	10	9	10	9	18	15
	NM_001714	BICD1	Bicaudal D homolog 1 (Drosophila)	230	562	*407*	197	447	*691*
	AK054944	LENG5	Leukocyte receptor cluster (LRC) member 5	67	100	91	78	74	*158*
Gene Expression
	NM_005088	DXYS155E	DNA segment on chromosome X and Y (unique) 155 expressed sequence	4857	3489	3214	5177	2241	2725
	NM_006298	ZNF192	Zinc finger protein 192	552	988	761	537	578	820
	NM_004991	MDS1	Myelodysplasia syndrome 1	401	691	480	390	361	420
	NM_021784	HNF3B	Hepatocyte nuclear factor 3, beta	320	632	367	347	361	391
	AF153201	LOC58502	C2H2 (Kruppel-type) zinc finger protein	288	532	335	244	297	324
	NM_025212	IDAX	Dvl-binding protein IDAX (inhibition of the Dvl and Axin complex)	297	490	311	303	254	241
	AK022962	PBX1	Pre-B-cell leukemia transcription factor 1	237	456	326	245	261	345
	NM_017617	NOTCH1	Notch-1 homolog	309	358	353	324	208	370
	NM_001451	FOXF1	Forkhead box F1	165	347	306	177	208	328
	NM_007136	ZNF80	Zinc finger protein 80 (pT17)	199	269	203	205	143	177
	NM_021975	RELA	V-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene	184	221	139	150	124	122
	NM_031214	TARDBP	TAR DNA binding protein	76	154	109	74	91	90
	NM_014007	ZNF297B	Zinc finger protein 297B	109	137	122	109	77	111
	NM_014938	MONDOA	Mlx interactor	74	90	92	69	53	86
	NM_005822	DSCR1L1	Down syndrome critical region gene 1-like 1	45	80	30	40	27	26
	NM_004289	NFE2L3	Nuclear factor (erythroid-derived 2)-like 3	73	63	41	64	39	38
	NM_054023	SCGB3A2	Secretoglobin family 3a, member 2	37	59	45	43	34	49
	NM_012107	BP75	Bromodomain containing protein 75 kDa human homolog	44	51	34	37	22	30
	NM_007212	RNF2	Ring finger protein 2	48	40	30	45	18	26
	D89859	ZFP161	Zinc finger protein 161 homolog (mouse)	500	596	*4280*	458	481	*6699*
	NM_014335	CRI1	CREBBP/EP300 inhibitory protein 1	52	84	86	57	72	*196*
Immune Function
	NM_014889	MP1	Metalloprotease 1 (pitrilysin family)	352	401	398	379	260	351
	NM_014312	CTXL	Cortical thymocyte receptor (X. laevis CTX) like	386	370	375	392	224	299
	NM_002053	GBP1	Guanylate binding protein 1, interferon-inducible, 67 kD	259	369	334	245	214	251
	NM_005356	LCK	Lymphocyte-specific protein tyrosine kinase	186	206	187	235	124	181
	NM_000564	IL5RA	Interleukin 5 receptor, alpha	112	106	124	121	63	150
	NM_001311	CRIP1	Cysteine-rich protein 1 (intestinal)	45	31	39	49	60	43
	NM_002984	SCYA4	Small inducible cytokine A4 MIP1B	492	2001	*2483*	517	1523	*3897*
	NM_002983	SCYA3	Small inducible cytokine A3 MIP1A	248	1798	*2207*	185	1364	*3673*
	NM_014443	IL17B	Interleukin 17B	663	696	*681*	706	703	*1155*
	NM_006018	HM74	Putative chemokine receptor-GTP-binding protein	13	25	19	15	26	34
Miscellaneous Functions
	AB033041	VANGL2	Vang, van gogh-like 2 (Drosophila)	983	1246	1351	981	796	1304
	AK021444	POSTN	Periostin, osteoblast specific factor	569	917	789	522	479	629
	NM_003691	STK16	Serine/threonine kinase 16	403	777	458	395	348	393
	NM_006438	COLEC10	Collectin sub-family member 10 (C-type lectin)	284	762	500	260	351	528
	AK057699		FLJ33137 fis, clone UTERU1000077	375	637	613	369	392	616
	NM_017671	C20orf42	Chromosome 20 open reading frame 42	362	557	551	280	323	478
	AK054683	DCLRE1C	DNA cross-link repair 1C	486	555	574	476	293	515
	NM_033060	KAP4.10	Keratin associated protein 4.10	210	245	197	154	123	172
	AF319045	CNTNAP2	Contactin associated protein-like 2	112	215	173	120	113	176
	NM_001046	SLC12A2	Solute carrier family 12 (sodium/potassium/chloride transporters), member 2	158	148	184	146	86	161
	NM_016279	CDH9	Cadherin 9, type 2 (T1-cadherin)	77	112	69	65	51	64
	NM_014208	DSPP	Dentin sialophosphoprotein	60	90	64	57	53	59
	NM_015669	PCDHB5	Protocadherin beta 5	92	83	62	98	42	47
	AK023198	OPRK1	Opioid receptor, kappa 1	58	76	41	48	46	38
	NM_018240	KIRREL	Kin of IRRE like (Drosophila)	60	75	47	66	43	46
	AK056781	ROCK1	Rho-associated, coiled-coil containing protein kinase 1	54	62	42	47	41	42
	NM_022123	NPAS3	Basic-helix-loop-helix-PAS protein	17	22	9	16	12	13
	NM_001246	ENTPD2	Ectonucleoside triphosphate diphosphohydrolase 2	3438	3272	*3731*	3767	3590	*6309*
Unknown Function
	AK056884		FLJ32322 fis, clone PROST2003577	2007	2878	2008	1825	1548	1958
	NM_017812	FLJ20420	Coiled-coil-helix-coiled-coil-helix domain containing 3	1105	1915	1370	1125	940	1358
	AJ420459	LOC51184	Protein x 0004	661	1579	881	603	771	768
	BC011575		Similar to RIKEN cDNA 0610031J06 gene, clone IMAGE:4639306	974	1556	1412	1020	844	1261
	AK057357	FLJ32926	DKFZp434D2472	1188	1378	1159	1043	515	1136
	NM_025019	TUBA4	tubulin, alpha 4	1446	1173	1330	1477	782	1366
	AK023150		FLJ13088 fis, clone NT2RP3002102	798	1087	905	845	564	785
	NM_017833	C21orf55	Chromosome 21 open reading frame 55	741	1079	799	687	508	665
	BC001407		Similar to cytochrome c-like antigen	524	1004	629	506	502	577
	AK023104		FLJ22648 fis, clone HSI07329	441	984	621	488	471	495
	AK024617		FLJ20964 fis, clone ADSH00902	824	955	745	788	535	824
	BC009536		IMAGE:3892368	553	924	775	597	498	671
	AK056287		FLJ31725 fis, clone NT2RI2006716	435	862	907	405	459	893
	AK021611		FLJ11549 fis, clone HEMBA1002968	535	812	675	545	392	630
	BC015119		IMAGE:3951139	445	784	487	455	435	439
	AK056492		FLJ31930 fis, clone NT2RP7006162	252	651	525	266	367	457
	AB058711	KIAA1808	KIAA1808 protein	208	637	357	199	339	366
	BC011266		IMAGE:4156795	354	632	432	356	328	460
	AK023316		FLJ13254 fis, clone OVARC1000787	416	596	357	400	290	352
	NM_024696	FLJ23058	Hypothetical protein FLJ23058	456	541	346	436	313	359
	AF253316		Pheromone receptor (PHRET) pseudogene	136	520	425	128	301	347
	AK056007	BICD1	Bicaudal D homolog 1 (Drosophila)	704	505	439	624	243	305
	AB020632	KIAA0825	KIAA0825 protein	249	498	353	246	272	339
	NM_017609	DKFZp434A1721	Hypothetical protein DKFZp434A1721	182	485	319	190	298	304
	NM_018190	FLJ10715	Hypothetical protein FLJ10715	202	483	310	174	206	266
	AK057046		FLJ32484 fis, clone SKNMC2001555	229	473	294	261	302	228
	NM_013395	AD013	Proteinx0008	448	461	496	403	304	378
	BC008501	MGC14839	Similar to RIKEN cDNA 2310030G06	379	414	329	443	264	290
	AK021988		FLJ11926 fis, clone HEMBB1000374	321	411	399	280	218	288
	AF119872		PRO2272	257	405	327	257	205	250
	NM_022744	FLJ13868	Hypothetical protein FLJ13868	267	376	239	270	212	172
	AK022364		FLJ12302 fis, clone MAMMA1001864	172	355	316	164	184	332
	BC002644	MGC4859	Hypothetical protein MGC4859 similar to HSPA8	282	335	382	257	223	331
	AK022201		FLJ12139 fis, clone MAMMA1000339	267	302	152	235	123	131
	NM_017953	FLJ20729	Hypothetical protein FLJ20729	170	290	258	138	170	218
	AK057473		FLJ32911 fis, clone TESTI2006210	160	268	265	163	123	247
	U50383	RAI15	Retinoic acid induced 15	206	265	236	198	159	186
	AK027027		FLJ23374 fis, clone HEP16126	134	261	170	134	152	141
	AK057288		FLJ32726 fis, clone TESTI2000981	206	249	312	216	152	244
	U79280	PIPPIN	Ortholog of rat pippin	274	229	189	238	117	134
	AK023628		FLJ13566 fis, clone PLACE1008330	140	195	230	133	128	193
	NM_025263	CAT56	CAT56 protein	126	194	147	127	101	130
	AF311324		Ubiquitin-like fusion protein	191	189	179	190	106	138
	NM_005708	GPC6	Glypican 6	107	185	144	109	88	146
	AB037778	KIAA1357	KIAA1357 protein	153	180	156	149	118	146
	AK055939		FLJ31377 fis, clone NESOP1000087	152	167	179	136	105	173
	NM_018316	FLJ11078	Hypothetical protein FLJ11078	89	145	118	73	94	103
	AF402776	BIC	BIC noncoding mRNA	82	136	171	96	88	153
	BC003416		IMAGE:3450973	64	133	93	83	73	111
	AL137491		DKFZp434P1530	62	130	88	57	72	74
	AK057770		FLJ25041 fis, clone CBL03194	110	130	114	108	83	84
	AB058769	KIAA1866	KIAA1866 protein	89	126	122	102	83	91
	AB058747	WAC	WW domain-containing adapter with a coiled-coil region	60	124	103	57	76	77
	AK054885	C6orf31	Chromosome 6 open reading frame 31	51	119	108	41	68	119
	AK022235		FLJ12173 fis, clone MAMMA1000696	109	103	94	90	62	77
	AK026853	AOAH	Acyloxyacyl hydrolase (neutrophil)	59	98	64	59	61	56
	AK024877		FLJ21224 fis, clone COL00694	53	96	110	55	54	103
	NM_003171	SUPV3L1	Suppressor of var1, 3-like 1 (S. cerevisiae)	65	93	60	60	55	58
	NM_052933	TSGA13	Testis specific, 13	66	80	70	68	44	71
	AK057907		FLJ25178 fis, clone CBR09176	42	77	31	47	43	41
	AK055748		FLJ31186 fis, clone KIDNE2000335	88	67	68	79	44	71
	BC013757		IMAGE:4525041	40	54	39	43	33	32
	AL365511		Novel human gene mapping to chomosome 22	19	48	29	20	27	37
	AK026889	APRIN	Androgen-induced proliferation inhibitor	31	35	42	34	21	34
	AK057423		FLJ32861 fis, clone TESTI2003589	36	32	34	30	18	31
	AK055543	MLSTD1	Male sterility domain containing 1	31	31	32	27	18	30
	AK056513		FLJ31951 fis, clone NT2RP7007177	33	29	20	22	13	20
	NM_013319	TERE1	Transitional epithelia response protein	22	28	19	24	17	22
	AK026456		FLJ22803 fis, clone KAIA2685	15	26	14	16	13	17
	AK021610		cDNA FLJ11548 fis, clone HEMBA1002944	34	26	29	31	15	28
	AK026823		FLJ23170 fis, clone LNG09984	15	22	14	19	8	18
	AK056805		FLJ32243 fis, clone PROST1000039	400	*177*	186	343	*314*	160
	NM_012238	SIRT1	Sirtuin silent mating type information regulation 2 homolog 1 (S. cerevisiae)	149	156	170	178	134	109
	NM_016099	GOLGA7	golgi autoantigen, golgin subfamily a, 7	10493	15165	*9882*	11947	11564	*15698*
	AK022482		FLJ12420 fis, clone MAMMA1003049	6052	9099	*5803*	6362	7620	*9309*
	AK026490	RAB32	RAB32, member RAS oncogene family	3677	7044	*4641*	3671	5553	*7561*
	NM_020684	NPD007	NPD007 protein	674	794	*764*	630	720	*1215*
	AL390158	ATXN7L3	Ataxin 7-like 3	319	460	*378*	339	403	*598*
	NM_017752	FLJ20298	Hypothetical protein FLJ20298	146	237	*282*	133	233	*493*
	AB037743	KIAA1322	KIAA1322 protein	236	202	*199*	239	246	*319*
	AF339819		clone IMAGE:38177	77	111	*110*	96	125	*174*
	AK055215		FLJ30653 fis, clone DFNES2000143	47	48	58	43	80	92

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