Soy isoflavones avert chronic inflammation-induced bone loss and vascular disease

Journal of Inflammation

Table 4 Biomechanical properties of trabecular bone in the distal femur.

Treatment	Total Force (N)	Physiological Force (N)	Stiffness (N/m × 10³)	Size Independent Stiffness (N/m²)	Von Mises Stress (MPa)
0 IF Placebo	272.51 ± 33.62^a	81.75 ± 10.09^a	435.24 ± 52.46^a	309.18 ± 36.02^a	15.49 ± 1.41^a
0 IF LPS	173.95 ± 56.94^b	52.19 ± 17.08^b	277.19 ± 90.74^b	183.87 ± 58.53^b	35.94 ± 10.22^b
126 IF Placebo	272.43 ± 68.25^a	81.73 ± 20.47^a	432.74 ± 107.88^a	299.34 ± 72.88^a	25.75 ± 9.86^a
126 IF LPS	111.29 ± 16.51^b	33.39 ± 5.00^b	177.58 ± 26.20^b	128.93 ± 21.01^b	32.19 ± 5.46^b
504 IF Placebo	205.29 ± 40.16^a	61.59 ± 12.05^a	327.76 ± 64.41^a	235.51 ± 46.35^a	26.54 ± 8.11^a
504 IF LPS	214.20 ± 65.75^b	64.26 ± 17.73^b	340.86 ± 104.08^b	251.69 ± 78.52^b	29.92 ± 7.83^b
P-values
LPS	0.0500	0.0500	0.0487	0.0500	0.1617
IF	0.8232	0.8232	0.8144	0.8148	0.8431
*LPSIF**	0.2475	0.2475	0.2497	0.2388	0.9095

Mice were fed soy isoflavones (IF; 0, 126 or 504 mg aglycone equivalents of IF/kg diet) for 14-days prior to and during a 30-day exposure to LPS (1.33 μg/d). Biomechanical properties were determined using simulated compression strength testing with finite element analysis. Results are expressed as means ± standard error. Values for a given parameter that share the same superscript letter are not statistically different (P > 0.05) from each other.

ISSN: 1476-9255