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Table 4 Biomechanical properties of trabecular bone in the distal femur.

From: Soy isoflavones avert chronic inflammation-induced bone loss and vascular disease

Treatment Total Force (N) Physiological Force (N) Stiffness (N/m × 103) Size Independent Stiffness (N/m2) Von Mises Stress (MPa)
0 IF Placebo 272.51 ± 33.62a 81.75 ± 10.09a 435.24 ± 52.46a 309.18 ± 36.02a 15.49 ± 1.41a
0 IF LPS 173.95 ± 56.94b 52.19 ± 17.08b 277.19 ± 90.74b 183.87 ± 58.53b 35.94 ± 10.22b
126 IF Placebo 272.43 ± 68.25a 81.73 ± 20.47a 432.74 ± 107.88a 299.34 ± 72.88a 25.75 ± 9.86a
126 IF LPS 111.29 ± 16.51b 33.39 ± 5.00b 177.58 ± 26.20b 128.93 ± 21.01b 32.19 ± 5.46b
504 IF Placebo 205.29 ± 40.16a 61.59 ± 12.05a 327.76 ± 64.41a 235.51 ± 46.35a 26.54 ± 8.11a
504 IF LPS 214.20 ± 65.75b 64.26 ± 17.73b 340.86 ± 104.08b 251.69 ± 78.52b 29.92 ± 7.83b
P-values      
LPS 0.0500 0.0500 0.0487 0.0500 0.1617
IF 0.8232 0.8232 0.8144 0.8148 0.8431
LPS*IF 0.2475 0.2475 0.2497 0.2388 0.9095
  1. Mice were fed soy isoflavones (IF; 0, 126 or 504 mg aglycone equivalents of IF/kg diet) for 14-days prior to and during a 30-day exposure to LPS (1.33 μg/d). Biomechanical properties were determined using simulated compression strength testing with finite element analysis. Results are expressed as means ± standard error. Values for a given parameter that share the same superscript letter are not statistically different (P > 0.05) from each other.