Time-course of plasma TNF-α, IL-6, KC, and MIP-2 levels following various reperfusion times, after the onset of 90 minutes of ischemia. "Control" indicates mice that underwent no surgical procedure. "Sham" indicates mice that underwent surgical procedure with no vascular occlusion followed by reperfusion, while "I/R" indicates mice that underwent surgical procedure with vascular occlusion for 90 minutes followed by reperfusion for various lengths of time. Values are expressed as mean ± SEM. *P < 0.05 wild-type group vs. P/I group (n = 3–16 mice per each time point/group). A: TNF-α data; B: IL-6 data; C: KC data; D: MIP-2 data.