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Table 1 Effects of inflammatory mediators on epithelial ion transport protein activity and expression.

From: Changes in ion transport in inflammatory disease

Type of ion transport
system [references]
Respiratory tract Gut Kidney
  TNF IL-1 IL-4 IL-9 IL-13 IFNg TGF Leukotrienes TNF IL-1 IL-3 IL-4 IL-10 IFNg TGF Subst P bradykinin IL-1 TGF bradykinin epoxide
CFTR                      
activity
[9,23,24,49,50,82,83,93]
  +/- a,b +    - - +a + a,b + a,b + a - - - - + a,c +   -   
expression
[9, 24, 49, 50, 82, 83, 86, 93]
  + +    - -   - +/-   -   - -     -   
ENaC                      
activity
[21, 24, 45, 46, 48, 49]
+/- a,b - -     +              -  
expression
[44, 45, 46, 47, 49, 89, 90]
- +/- -     -   - -     -        
Na/K ATPase                      
activity
[30, 56, 57, 58, 59, 88, 98, 99, 108, 109]
        +a -      - -    -a,b   +/-a -
expression
[47, 48, 87, 88, 91, 100]
  +      +   -a -     -     -    
Non CFTR Cl - channel                      
activity [51, 133] + +     +                +
expression [51, 52, 113]    + + + +                +
Na/K 2Cl - co-transporter          -             
activity [88]          -             
expression [87, 88, 91]          -a +     -        
  1. + = increase
  2. -=decrease
  3. +/- = increase or decrease depending on experimental conditions and possibly second messenger involved
  4. a mediated through PGE2
  5. b mediated through NO
  6. c mediated through histamine