Type of ion transport system [references] | Respiratory tract | Gut | Kidney | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | TNF | IL-1 | IL-4 | IL-9 | IL-13 | IFNg | TGF | Leukotrienes | TNF | IL-1 | IL-3 | IL-4 | IL-10 | IFNg | TGF | Subst P | bradykinin | IL-1 | TGF | bradykinin | epoxide |
CFTR | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
activity [9,23,24,49,50,82,83,93] | Â | +/- a,b | + | Â | Â | - | - | +a | + a,b | + a,b | + a | - | - | - | - | + a,c | + | Â | - | Â | Â |
expression [9, 24, 49, 50, 82, 83, 86, 93] | Â | + | + | Â | Â | - | - | Â | - | +/- | Â | - | Â | - | - | Â | Â | Â | - | Â | Â |
ENaC | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
activity [21, 24, 45, 46, 48, 49] | +/- a,b | - | - | Â | Â | Â | + | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | - | Â |
expression [44, 45, 46, 47, 49, 89, 90] | - | +/- | - | Â | Â | Â | - | Â | - | - | Â | Â | Â | - | Â | Â | Â | Â | Â | Â | Â |
Na/K ATPase | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
activity [30, 56, 57, 58, 59, 88, 98, 99, 108, 109] | Â | Â | Â | Â | Â | Â | Â | +a | - | Â | Â | Â | Â | - | - | Â | Â | -a,b | Â | +/-a | - |
expression [47, 48, 87, 88, 91, 100] | Â | + | Â | Â | Â | Â | + | Â | -a | - | Â | Â | Â | - | Â | Â | Â | - | Â | Â | Â |
Non CFTR Cl - channel | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
activity [51, 133] | + | + | Â | Â | Â | + | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | + |
expression [51, 52, 113] | Â | Â | + | + | + | + | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | + |
Na/K 2Cl - co-transporter | Â | Â | Â | Â | Â | Â | Â | Â | - | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
activity [88] | Â | Â | Â | Â | Â | Â | Â | Â | - | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
expression [87, 88, 91] | Â | Â | Â | Â | Â | Â | Â | Â | -a | + | Â | Â | Â | - | Â | Â | Â | Â | Â | Â | Â |