Figure 3

Effect of aspirin and salicylic acid (10 μM – 1 mM) on EPR signals generated from PGHS-1 after treatment with substrate (AA). In each case, incubations with aspirin or SA were for 10 min prior to the baseline EPR reading (t = -2 min, not shown). AA was added at t = 0 min and readings shown were taken at t = 1.5 min. *P < 0.05, **P < 0.01; 1-way ANOVA with Dunnett's post-hoc test vs. control: n = 8–10.