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Table 1 The effects of RU24858, mometasone and dexamethasone on IL-5 induced human eosinophil survival. Apoptosis was analyzed by morphological criteria. Results are expressed as percentage of apoptotic cells. Values are the mean ± S.E.M., n = 6. * Indicates P < 0.05, ** P < 0.01, *** P < 0.001 as compared with the respective control in the absence of glucocorticoids.

From: The glucocorticoid RU24858 does not distinguish between transrepression and transactivation in primary human eosinophils

 

Apoptotic eosinophils (%)

 

Control

1 nM IL-5

10 nM IL-5

control

43.3 ± 6.7

8.1 ± 1.5

9.3 ± 2.5

RU24858 1 μM

51.9 ± 5.5 *

11.6 ± 3.4

10.8 ± 3.8

Mometasone 1 μM

63.1 ± 6.8 ***

16.0 ± 2.9 **

10.8 ± 3.6

Dexamethasone 1 μM

60.1 ± 4.4 **

17.1 ± 3.3 **

7.7 ± 2.6