Immunohistochemical localization of ICAM-1 in the lung. When compared to lung sections taken from sham group (A), lung sections from carrageenin-treated rats (B) demonstrated intense positive brown staining for ICAM-1 (black arrow). The degree of tissue staining for ICAM-1 from carrageenin-treated rats that had received PACs (10, 30 and 60 mg/kg, respectively C, D and E) was markedly reduced. Original magnification: × 125. This figure is representative of six experiments performed on different animals.