Figure 7
From: CXCR2 is critical for dsRNA-induced lung injury: relevance to viral lung infection
Inhibition of CXCR2 inhibits dsRNA-induced neutrophil recruitment and attenuates dsRNA-induced lung injury. (A) Total cells via BAL fluid cell count at 72 h (n = 4; *p < 0.05). (B) Wet:Dry ratio at 72 h (n = 6 mice per group; *p < 0.05). (C) Evans blue permeability index at 72 h (n = 6 mice per group; *p < 0.05). (D) Histopathology of lungs at 72 h following dsRNA treatment. Representative photomicrographs with H & E staining (100X; n = 4 mice per group). Mice were pretreated with normal goat serum (control Ab) or anti-CXCR2 Ab at times -24, 0, 24, and 48 h following IT dsRNA treatment.