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Table 2 Effect of Dex on IFN-γ, IL-4 and IL-9 secretion.

From: Dexamethasone inhibits IL-9 production by human T cells

Cytokine

OKT3 range

OKT3 plus Dex range

% cytokine in Dex vs no Dex

IFN-γ (ng/mL)

11–56

0.15–1.1

2.4 ± 2.1

IL-4 (pg/mL)

23–81

12–22

31 ± 14

§ IL-9 (pg/mL)

234–781

* undetectable

4.3 ± 2.9

  1. PBMC from 6 different individuals were activated with OKT3 and treated with or without 10-6 M Dex. Cytokine concentration was measured in triplicate. For each individual, the % cytokine secretion in Dex versus no Dex was determined, and the Table shows the mean ± SD of these values. § The IL-9 data are for these 6 individuals only; the results are not significantly different from the results for all 11 individuals shown in Fig. 3. * For IL-9, all the Dex treated samples were below the lower limit of detection of the assay which was 7.8–15.8 pg/mL. The latter figures were used to calculate the % cytokine figure.
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Journal of Inflammation

ISSN: 1476-9255

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