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Table 9 Laboratory-based evaluations of safety

From: Early relief of osteoarthritis symptoms with a natural mineral supplement and a herbomineral combination: A randomized controlled trial [ISRCTN38432711]

Test Placebo Wk. 0 Placebo Wk. 8 A Wk. 0 A Wk. 8 B Wk. 0 B Wk. 8 C Wk. 0 C Wk. 8
Neu 62.0 ± 1.7 64.2 ± 2.1 59.3 ± 2.4 58.6 ± 2.3 64.7 ± 1.6 61.5 ± 1.6 61.6 ± 1.5 63.0 ± 1.7
Bas 0 0 0 0 0 0 0 0.3 ± 0.3
Eos 3.6 ± 0.8 3.6 ± 0.6 4.2 ± 0.5 3.7 ± 0.9 4.0 ± 0.6 4.8 ± 1.5 3.9 ± 0.5 4.4 ± 0.5
Lym 34.0 ± 2.0 31.7 ± 2.5 35.7 ± 2.5 35.2 ± 1.8 30.3 ± 1.8 34.3 ± 1.8* 33.4 ± 1.7 31.8 ± 1.8
Mon 0.8 ± 0.3 0.6 ± 0.2 1.0 ± 0.2 0.8 ± 0.3 0.9 ± 0.2 0.7 ± 0.2 1.1 ± 0.2 0.7 ± 0.2
WBC 8052 ± 417 8260 ± 499 7994 ± 514 8037 ± 655 8750 ± 476 7857 ± 478 8160 ± 308 7815 ± 459
RBC 3.98 ± 0.09 4.11 ± 0.11 4.26 ± 0.09 4.41 ± 0.12 4.33 ± 0.11 4.31 ± 0.10 4.39 ± 0.12 4.30 ± 0.10
HB 12.0 ± 0.2 12.4 ± 0.4 12.0 ± 0.2 12.5 ± 0.3* 12.2 ± 0.3 12.1 ± 0.3 12.3 ± .2 12.2 ± 0.3
ESR 29.0 ± 3.6 32.4 ± 6.0 35.0 ± 3.5 30.5 ± 4.8 31.7 ± 4.2 40.7 ± 6.2 26.5 ± 3.6 22.2 ± 3.2
SGPT 28.8 ± 1.9 27.7 ± 2.4 23.6 ± 1.9 29.3 ± 4.5 24.5 ± 1.6 25.6 ± 1.7 24.9 ± 1.1 26.4 ± 3.3
CRE 0.98 ± 0.04 0.97 ± 0.05 1.4 ± 0.4 0.9 ± 0.04 1.7 ± 0.7 1.0 ± 0.03 1.67 ± 0.69 1.01 ± 0.05
  1. Data expressed as a mean ± sem. Group A = High dose sierrasil (n = 20), Group B = Low dose sierrasil (n = 21), Group C = Low dose sierrasil + cat's claw extract (n = 25), placebo n = 22.
  2. Neu = neutrophils %, Bas = basophils %, Eos = eosinophils %, Lym = lymphocytes %, Mon = monocytes %, WBC = white blood cells per mm3, RBC = red blood cells 106 × mm3, HB = hemoglobin gm/dl, ESR = erythrocyte sedimentation rate mm, SGPT = IU/L, CRE = creatinine mg/dl. Using unpaired t test, the following descriptors describe a significant difference from baseline, * p < 0.05.