Early relief of osteoarthritis symptoms with a natural mineral supplement and a herbomineral combination: A randomized controlled trial [ISRCTN38432711]

Table 9 Laboratory-based evaluations of safety

Test	Placebo Wk. 0	Placebo Wk. 8	A Wk. 0	A Wk. 8	B Wk. 0	B Wk. 8	C Wk. 0	C Wk. 8
Neu	62.0 ± 1.7	64.2 ± 2.1	59.3 ± 2.4	58.6 ± 2.3	64.7 ± 1.6	61.5 ± 1.6	61.6 ± 1.5	63.0 ± 1.7
Bas	0	0	0	0	0	0	0	0.3 ± 0.3
Eos	3.6 ± 0.8	3.6 ± 0.6	4.2 ± 0.5	3.7 ± 0.9	4.0 ± 0.6	4.8 ± 1.5	3.9 ± 0.5	4.4 ± 0.5
Lym	34.0 ± 2.0	31.7 ± 2.5	35.7 ± 2.5	35.2 ± 1.8	30.3 ± 1.8	34.3 ± 1.8*	33.4 ± 1.7	31.8 ± 1.8
Mon	0.8 ± 0.3	0.6 ± 0.2	1.0 ± 0.2	0.8 ± 0.3	0.9 ± 0.2	0.7 ± 0.2	1.1 ± 0.2	0.7 ± 0.2
WBC	8052 ± 417	8260 ± 499	7994 ± 514	8037 ± 655	8750 ± 476	7857 ± 478	8160 ± 308	7815 ± 459
RBC	3.98 ± 0.09	4.11 ± 0.11	4.26 ± 0.09	4.41 ± 0.12	4.33 ± 0.11	4.31 ± 0.10	4.39 ± 0.12	4.30 ± 0.10
HB	12.0 ± 0.2	12.4 ± 0.4	12.0 ± 0.2	12.5 ± 0.3*	12.2 ± 0.3	12.1 ± 0.3	12.3 ± .2	12.2 ± 0.3
ESR	29.0 ± 3.6	32.4 ± 6.0	35.0 ± 3.5	30.5 ± 4.8	31.7 ± 4.2	40.7 ± 6.2	26.5 ± 3.6	22.2 ± 3.2
SGPT	28.8 ± 1.9	27.7 ± 2.4	23.6 ± 1.9	29.3 ± 4.5	24.5 ± 1.6	25.6 ± 1.7	24.9 ± 1.1	26.4 ± 3.3
CRE	0.98 ± 0.04	0.97 ± 0.05	1.4 ± 0.4	0.9 ± 0.04	1.7 ± 0.7	1.0 ± 0.03	1.67 ± 0.69	1.01 ± 0.05

Data expressed as a mean ± sem. Group A = High dose sierrasil (n = 20), Group B = Low dose sierrasil (n = 21), Group C = Low dose sierrasil + cat's claw extract (n = 25), placebo n = 22.
Neu = neutrophils %, Bas = basophils %, Eos = eosinophils %, Lym = lymphocytes %, Mon = monocytes %, WBC = white blood cells per mm³, RBC = red blood cells 10⁶ × mm³, HB = hemoglobin gm/dl, ESR = erythrocyte sedimentation rate mm, SGPT = IU/L, CRE = creatinine mg/dl. Using unpaired t test, the following descriptors describe a significant difference from baseline, * p < 0.05.

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