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Table 7 Sequential WOMAC Total – Summary

From: Early relief of osteoarthritis symptoms with a natural mineral supplement and a herbomineral combination: A randomized controlled trial [ISRCTN38432711]

Group Baseline Week 1 Week 2 Week 4 Week 6 Week 8
Placebo 48.6 ± 5.2 49.0 ± 5.8 46.6 ± 5.9 43.5 ± 5.8 38.8 ± 5.9 * 35.3 ± 6.3 **
A 51.5 ± 6.4 43.5 ± 6.9 41.4 ± 6.7 ** 35.0 ± 6.2 *** 36.2 ± 6.2 *** 31.8 ± 6.1 ***
B 46.4 ± 5.6 42.0 ± 5.9 * 38.6 ± 6.0 *** 32.6 ± 5.2 *** 31.5 ± 5.3 *** 28.5 ± 3.9 ***
C 44.8 ± 5.5 42.3 ± 5.2 39.0 ± 5.1 ** 32.0 ± 4.4 *** 28.7 ± 4.5 *** 25.6 ± 4.4 ***
  1. Data expressed as mean ± sem. Group A = High dose sierrasil (n = 20), Group B = Low dose sierrasil (n = 21), Group C = Low dose sierrasil + cat's claw extract (n = 25), placebo n = 22. All groups displayed a significant change over the 8 weeks of the study (p < 0.001, ANOVA). Using the Wilcoxan Matched-Pairs Signed-Rank test the following descriptors reflect statistical significance from baseline; * p < 0.05, ** p < 0.01, ** p < 0.001. Note the p values for groups A and C approached significance at week one (p = 0.051 and 0.053).