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Table 1 Ex vivo measurement of luciferase activity (Unit/μg protein). Selected organs were harvested from IkBα-luc mice that were untreated (control, n = 3) or treated with LPS (1 mg/kg, i.p., n = 3) at 4 hours prior to the harvesting.

From: Regulation of IκBα expression involves both NF-κB and the MAP kinase signaling pathways

 

Mean ± SE

 

MALE

FEMALE

ORGANS

Control

LPS

Control

LPS

Liver

157 ± 30

3651 ± 48*§

157 ± 2

2933 ± 69*

Spleen

363 ± 69

6906 ± 878*

218 ± 58

6203 ± 1414*

Lungs

430 ± 112

3549 ± 291*

348 ± 52

2718 ± 452*

Intestine

89 ± 39

4640 ± 601*

73 ± 9

1367 ± 598*

Kidney

65 ± 7

709 ± 62*

67 ± 5

414 ± 26*

Heart

15 ± 2§

951 ± 141*

7 ± 2

405 ± 8*

Brain

72 ± 13

513 ± 84*

73 ± 9

384 ± 52*

  1. *Difference from controls significant at P ≤ 0.05 by Mann-Whitney nonparametric test.
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Journal of Inflammation

ISSN: 1476-9255

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