Effect of MAP kinase inhibitors on LPS-induced luciferase expression. A. Female I κB α-luc transgenic mice were pre-treated with SB203580 (5 mg/kg, i.v., n = 5), PD098059 (10 mg/kg, i.v., n = 5), or SP600125 (20 mg/kg, i.v., n = 8) at 1 hour prior to the LPS treatment. The positive control mice were pre-injected with DMSO (n = 8). All the mice were imaged at T = 0, 2, 4, 7 and 24 hours after LPS treatment. Representative mice are shown for each group. B. Quantification of the luciferase signal from liver region and the data were expressed as photons/second/cm2.