Effect of bortezomib on LPS-induced luciferase expression. A. I κB α-luc transgenic mice were pre-treated with bortezomib (1 mg/kg, i.v. n = 5) at 1 hour prior to the LPS treatment. The positive control mice (n = 4 for males, n = 6 for females) were pre-injected with saline. All the mice were imaged at T = 0, 2, 4, 7 and 24 hours after the LPS treatment. B, C. Quantification of the luciferase signal from the abdominal region of the body for male and female mice respectively. Data are expressed as billion photons/second. Nonparametric significance levels for the difference between treatment groups were determined by a Mann-Whitney test and are presented above the bars.