Combination therapy with ampicillin and azithromycin in an experimental pneumococcal pneumonia is bactericidal and effective in down regulating inflammation in mice

Table 3 Pharmacokinetic and pharmacodynamic parameters ^a for ampicillin (AMP) and azithromycin (AZM) following a single intravenously administered dose of both drugs 18 h post infection

^aAbbreviations: C_max maximum concentration of drug in serum, C_min minimum concentration of the drug in serum, t_1/2 time taken to reach half of the maximum concentration, AUC area under the concentration-time curve from time zero to 6 h post antibiotic treatment, K_e- Elimination rate of the drug, T_>MIC Time during which the drug concentration remains above the MIC value in serum, AUC/MIC Ratio of area under the curve during 6 h of post antibiotic treatment to the MIC value for the S. pneumoniae strain AMRI-SP1, C_max/MIC ratio of maximum concentration of the drug achieved in serum to MIC of the drug.

ISSN: 1476-9255