Figure 8

Histology of lung tissue in normal mice (A); S. pneumoniae infected mice (B); treated with antibiotics ampicillin (AMP) (C) and/or azithromycin (AZM) (D) either alone or in combination (E) 18 hours post infection. Pictures were taken from 0 – 6 hours after initiation of therapy which corresponds to 18 – 24 hours post infection. Profuse neutrophil count, diffuse edema with swelling of interstitium was noted in untreated infected animals, while mice receiving combination therapy recovered very fast than monotherapy and had tissue profiles similar to those of healthy controls. Left panel shows histology of lung tissue at low magnification and right panel at high magnification. Arrow indicates accumulation of PMNs in the alveoli.