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Figure 6 | Journal of Inflammation

Figure 6

From: Combination therapy with ampicillin and azithromycin in an experimental pneumococcal pneumonia is bactericidal and effective in down regulating inflammation in mice

Figure 6

Expression of COX-2 after treatment with ampicillin in combination with azithromycin in lung tissue. Expression of COX-2 in lung tissue was measured in terms of fold change over S. pneumoniae infected untreated control. Highest level of COX-2 was found at 18 h post infection. Gradual reduction in COX-2 level was visible after treatment with ampicllin in combination with azithromycin with the decrease being most prominent at 4th hour post antibiotic treatment. S. pneumoniae AMRI SP -1 infected untreated control group versus S. pneumoniae AMRI SP-1 + ampicillin + azithromycin treated group (P < 0.01 significant decrease with respect to SP infected untreated control at 1-3 h post antibiotic treatment).

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