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Figure 6 | Journal of Inflammation

Figure 6

From: Salivary histatin 3 inhibits heat shock cognate protein 70-mediated inflammatory cytokine production through toll-like receptors in human gingival fibroblasts

Figure 6

The effect of histatin 3 on HSC70-stimulated inflammatory cytokine production in HGFs. (A) HSC70-stimulated IL-6 and (B) IL-8 production in the presence of histatin 3 in HGFs. HGFs were stimulated with HSC70 in the presence of control peptide (cont. pep.), P3a, or histatin 3 for 24 h, and the amounts of IL-6 and IL-8 in the culture media were measured by ELISAs. Bars represent the means and range of duplicate samples. ***, P < 0.001 versus stimulation with HSC70 alone. (C) IL-6 and (D) IL-8 production in HGFs after stimulation with HSC70 in the presence of histatin family members. HGFs were stimulated with HSC70 in the presence of histatins 3, 4, or 5 for 24 h, and the amounts of IL-6 and IL-8 in the culture media were measured by ELISAs. Bars represent the means and range of duplicate samples. ***, P < 0.001 versus stimulation with HSC70 alone. ††, P < 0.01; †††, P < 0.001.

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Journal of Inflammation

ISSN: 1476-9255

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