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Figure 3 | Journal of Inflammation

Figure 3

From: Salivary histatin 3 inhibits heat shock cognate protein 70-mediated inflammatory cytokine production through toll-like receptors in human gingival fibroblasts

Figure 3

The effect of DSG on NF-κB-dependent activation by HSC70 through TLR2 and TLR4 in the presence of histatin 3. One day after transfection with pIgκB-Luc in 293-TLR4/MD2-CD14 (A) and 293-TLR2/CD14 (B) cells, the cells were stimulated with HSC70 with or without histatin 3 in the presence or absence of DSG for 6 h. Cell lysates prepared from the stimulated cells were analyzed by luciferase assays. The values are shown as fold induction of the standardized luciferase activity over the unstimulated control (none, DSG (-)). Bars represent the means and range of duplicate samples. *, P < 0.05; **, P < 0.01, ***, P < 0.001 versus stimulation with HSC70 alone. †††, P < 0.001.

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Journal of Inflammation

ISSN: 1476-9255

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