Table 1 Selective inhibitors of NF- κ B signaling pathways that inhibits IKK activity and I κ B α phosphorylation and/or degradation
Molecule | Point of inhibition | References |
|---|---|---|
BMS-345541 (4(2-Aminoethyl)amino-1,8-dimethylimidazo(1,2-a) quinoxaline) and 4-amino derivatives | IKK α and IKK β kinase activity | [210] |
2-amino-3-cyano-4-aryl-6-(2-hydroxy-phenyl)pyridine derivatives | IKK β activity | [211] |
Acrolein | IKK β activity/p50 DNA binding | [212] |
1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl] imidazole | IKK β activity | [213] |
Dihydroxyphenylethanol | IKK β activity | [214] |
MLB120 (small molecule) | IKK β activity | [215] |
SC-514 (small molecule) | IKK β activity | |
Thienopyridine | IKKb activity | [217] |
Amino-pyrimidine derivative | IKK activity | [58] |
Benzoimidazole derivative | IKK activity | [58] |
Butein | IKK β activity | [218] |
Beta-carboline | IKK activity | [219] |
Berberine | IKK β activity | [220] |
IMD-0354 | IKK β activity | [221] |
PS-1145 (MLN1145) | IKK β activity | [222] |
17-Acetoxyjolkinolide B | IKK activity | [223] |
CML-1 | IKK activity | [224] |
CT20126 | IKK activity/NIK | [225] |
Furonaphthoquinone | IKK activity | [226] |
3-Formylchromone | IKK β activity/p65 DNA binding | [227] |
Indolecarboxamide derivative | IKK activity | [58] |
(Amino) imidazolylcarboxaldehyde derivative | IKK activity | [58] |
Imidazolylquinoline-carboxaldehyde derivative | IKK activity | [58] |
ML120B | IKK activity | [228] |
Pinitol | IKK activity | [229] |
PMX464 | IKK activity | [230] |
Pyrazolo[4,3-c]quinoline derivative | IKK activity | [58] |
Pyridooxazinone derivative | IKK activity | [58] |
N-(4-hydroxyphenyl) retinamide | IKK activity | [231] |
Thalidomide (and thalidomide analogs) | IKK activity | [232] |
Salubrinal | IKK activity/degradation | [233] |
GS143 | Blocks I κ B ubiquitylation | [208] |
Delphinidin | Phosphorylation | [234] |
Digitoxin | Phosphorylation | [235] |
Dihydrotestosterone | Phosphorylation | [236] |
Kaempferol | Phosphorylation | [237] |
Tomatidine | Phosphorylation | [238] |
Allylpyrocatechol | Degradation | [239] |
Clomipramine/imipramine | Degradation | [240] |
Glucosamine (sulfate or carboxybutyrylated) | Degradation | [241] |
Losartan | Degradation/NF- κ B expression | [242] |
Pectenotoxin-2 | Degradation | [243] |
Sevoflurane/isoflurane | Degradation | [244] |