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Table 1 Selective inhibitors of NF- κ B signaling pathways that inhibits IKK activity and I κ B α phosphorylation and/or degradation

From: Chronic inflammation and cancer: potential chemoprevention through nuclear factor kappa B and p53 mutual antagonism

Molecule Point of inhibition References
BMS-345541 (4(2-Aminoethyl)amino-1,8-dimethylimidazo(1,2-a) quinoxaline) and 4-amino derivatives IKK α and IKK β kinase activity [210]
2-amino-3-cyano-4-aryl-6-(2-hydroxy-phenyl)pyridine derivatives IKK β activity [211]
Acrolein IKK β activity/p50 DNA binding [212]
1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl] imidazole IKK β activity [213]
Dihydroxyphenylethanol IKK β activity [214]
MLB120 (small molecule) IKK β activity [215]
SC-514 (small molecule) IKK β activity [215, 216]
Thienopyridine IKKb activity [217]
Amino-pyrimidine derivative IKK activity [58]
Benzoimidazole derivative IKK activity [58]
Butein IKK β activity [218]
Beta-carboline IKK activity [219]
Berberine IKK β activity [220]
IMD-0354 IKK β activity [221]
PS-1145 (MLN1145) IKK β activity [222]
17-Acetoxyjolkinolide B IKK activity [223]
CML-1 IKK activity [224]
CT20126 IKK activity/NIK [225]
Furonaphthoquinone IKK activity [226]
3-Formylchromone IKK β activity/p65 DNA binding [227]
Indolecarboxamide derivative IKK activity [58]
(Amino) imidazolylcarboxaldehyde derivative IKK activity [58]
Imidazolylquinoline-carboxaldehyde derivative IKK activity [58]
ML120B IKK activity [228]
Pinitol IKK activity [229]
PMX464 IKK activity [230]
Pyrazolo[4,3-c]quinoline derivative IKK activity [58]
Pyridooxazinone derivative IKK activity [58]
N-(4-hydroxyphenyl) retinamide IKK activity [231]
Thalidomide (and thalidomide analogs) IKK activity [232]
Salubrinal IKK activity/degradation [233]
GS143 Blocks I κ B ubiquitylation [208]
Delphinidin Phosphorylation [234]
Digitoxin Phosphorylation [235]
Dihydrotestosterone Phosphorylation [236]
Kaempferol Phosphorylation [237]
Tomatidine Phosphorylation [238]
Allylpyrocatechol Degradation [239]
Clomipramine/imipramine Degradation [240]
Glucosamine (sulfate or carboxybutyrylated) Degradation [241]
Losartan Degradation/NF- κ B expression [242]
Pectenotoxin-2 Degradation [243]
Sevoflurane/isoflurane Degradation [244]