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Table 2 Relation of baseline risk factors to baseline CRP, peak post-operative CRP and absolute change in CRP following surgery

From: Abdominal adiposity is the main determinant of the C-reactive response to injury in subjects undergoing inguinal hernia repair

 

Baseline CRP (proportional change)

Peak CRP (proportional change)

Difference in peak CRP peak and baseline(proportional change)

Baseline CRP (per 10 fold increase)

 

2.44 (1.76-3.38) p < 0.0001

1.23 (0.86-1.76) ns

Waist:hip ratio (per 10% increase)

1.70 (1.22-2.37) p = 0.0022

1.86 (1.44-2.40) p < 0.0001

1.52 (1.17-1.98) p = 0.0019

BMI(per unit change)

1.06 (0.97-1.16) p = 0.16

1.05 (0.97-1.12) p = 0.24

1.06 (0.99-1.14) p = 0.1

Waist circumference (per 10 cm increase)

1.68 (1.28- 2.20) p = 0.0002

1.60 (1.29- 1.98)

1.43 (1.15- 1.77) p = 0.0015

P < 0.0001

Weight (per 10 kg increase)

1.21 (0.95-1.52)

1.14 (0.95-1.39)

1.16 (0.97-1.39) p = 0.09

Age (per decade)

1.38 (1.15-1.66) p = 0.0006

1.32 (1.14-1.52) p = 0.0003

1.18 (1.02-1.37) p = 0.02

Duration of surgery (per minute)

1.05 (1.01-1.11) p = 0.04

1.06 (1.02-1.10) p = 0.003

1.05 (1.02-1.09) p = 0.007

Wound length (per cm)

1.46 (1.06-2.00) p = 0.02

1.33 (1.03-1.73) p = 0.03

1.28 (0.99-1.65) p = 0.06

*Ethnic Group: n, %

White Caucasian

1.46 (1.00-2.63)

1.38 (0.91- 1.51)

1.17 (0.78- 1.74)

Afro Carib

1.27 (0.66- 2.43)

0.83 (0.55- 1.50)

0.87 (0.50- 1.73)

Asian

1.67 (0.73- 3.84)

1.15 (0.55- 2.40)

1.12 (0.54- 2.30)

Other (ref)

0.29 P = 0.06

0.75

0.88

*Smoking status (%)

Current (reference)

0.80

0.87

0.93 (0.70-1.24)

Ex

1.66 (1,12- 2.45)

1.30 (0.95- 1,78)

1.13 (0.82- 1.56)

Never

0.76 (0.53- 1.08) P = 0.04

0.88 (0.66- 1.17)

0.95

Exercise

<2 × /week (reference)

   

2 + ×/week

0.64 (0.36-1.13) p = 0.12

0.95 (0.59-1.52)

1.14 (0.72-1.79)

*Occupation

Manual (reference)

0.73 (0.47- 1.14)

0.68 (0.48- 0.96)

0.69 (0.48- 0.99)

Non-manual

0.80 (0.54- 1.17)

1.06 (0.78- 1.43)

1.18 (0.87- 1.60)

retired

1.73 p = 0.007

1.39 P = 0.1

1.23 P = 0.002

Anti-hypertensive medication

1.63 (0.86-3.10)

1.91 (1.13-2.61) p = 0.02

1.82 (1,10-2.61) P = 0.02

  1. CRP was log transformed for the purposes of analysis of baseline CRP and post-operative CRP and the absolute difference in pre-op and post-operative CRP was log transformed after adding 1 to the difference.
  2. *ANOVA coefficients, statistical significance determined by ANOVA.