Table 1 Comparison of LV remodelling and function before (4 months) and after (8 months) hypertension
From: Prenatal exposure to lipopolysaccharide results in myocardial remodelling in adult murine offspring
Age (4 months) | Age (8 months) | |||||
|---|---|---|---|---|---|---|
Control | LPS | LPS + PDTC | Control | LPS | LPS + PDTC | |
HR (bpm) | 336 ± 12 | 340 ± 27 | 338 ± 36 | 308 ± 5 | 302 ± 7 | 306 ± 9 |
LVEDD (mm) | 7.47 ± 0.25 | 7.78 ± 0.30 | 7.44 ± 0.28 | 7.83 ± 0.36 | 7.94 ± 0.56 | 7.79 ± 0.35 |
LVESD (mm) | 4.11 ± 0.22 | 3.81 ± 0.12 | 4.08 ± 0.29 | 4.27 ± 0.30 | 3.78 ± 0.28* | 4.13 ± 0.15# |
PWT (mm) | 2.02 ± 0.15 | 2.49 ± 0.23* | 1.99 ± 0.11# | 2.42 ± 0.07 | 2.57 ± 0.10* | 2.45 ± 0.27# |
IVST (mm) | 1.88 ± 0.18 | 1.66 ± 0.27 | 1.81 ± 0.17 | 2.01 ± 0.04 | 2.20 ± 0.10* | 2.02 ± 0.03# |
Mitral E maximum | ||||||
vel. (mm/s) | 1130 ± 46 | 1267 ± 192 | 1283 ± 303 | 1281 ± 105 | 1305 ± 79 | 1291 ± 124 |
Mitral A maximum | ||||||
vel. (mm/s) | 691 ± 17 | 693 ± 46 | 671 ± 31 | 908 ± 63 | 572 ± 43* | 916 ± 57# |
Mitral E/A index | 1.63 ± 0.05 | 1.83 ± 0.23 | 1.93 ± 0.54 | 1.41 ± 0.14 | 2.28 ± 0.15* | 1.41 ± 0.14# |
Mitral deceleration time (ms) | 48.65 ± 2.97 | 44.67 ± 6.28 | 49.45 ± 4.95 | 42.05 ± 3.80 | 32.12 ± 3.17* | 41.43 ± 2.67# |
Myocardial performance (Tei) index | 0.35 ± 0.02 | 0.42 ± 0.03 | 0.39 ± 0.01 | 0.34 ± 0.02 | 0.48 ± 0.03* | 0.34 ± 0.02# |
Parasternal short-axis | ||||||
FS (%) | 45 ± 4.7 | 51 ± 1.6 | 45 ± 5.8 | 45 ± 5.1 | 48 ± 2.0 | 47 ± 4.3 |
EF (%) | 75 ± 5.2 | 80 ± 4.7 | 74 ± 6.3 | 75 ± 5.4 | 78 ± 1.8 | 77 ± 4.4 |
Parasternal long-axis apical | ||||||
Ao end-systolic diameter (mm) | 3.54 ± 0.28 | 3.40 ± 0.66 | 3.56 ± 0.14 | 3.75 ± 0.12 | 3.91 ± 0.13 | 3.80 ± 0.12 |
Vp (cm/s) | 1322 ± 88.6 | 1233 ± 109.1 | 1354 ± 154.6 | 1160 ± 117.1 | 1040 ± 180.3 | 1146 ± 101.3 |
VTI (mmHg) | 8.22 ± 0.15 | 8.53 ± 0.32 | 8.35 ± 0.33 | 7.76 ± 0.54 | 7.88 ± 0.68 | 7.64 ± 0.59 |