Figure 2
Atherosclerotic plaques in the aorta. (A, C, E) Representative photomicrographs of control (cont) and diabetic ApoE KO mice (STZ) showing that STZ-induced diabetes accelerates the progression of atherosclerotic lesions in the whole aorta, aortic arch, and aortic root. (B, D, F) Quantitative measurement of the en face plaque area (%) in the whole aorta (B) and aortic arch (D), and oil red-O-stained plaque area (mm2) in the aortic root (F) (n = 9 mice/group). Each bar indicates mean ± S.D. *P < 0.05 and **P < 0.01 vs control mice.