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Table 2 Baseline characteristics of 100 patients presenting with AECOPD to the ICU within the first 24 hours

From: Low Serum retinol-binding protein-4 levels in acute exacerbations of chronic obstructive pulmonary disease at intensive care unit admission is a predictor of mortality in elderly patients

Parameter

All patients

Survivors

Non-survivors

p value

Number

100

36

64

 

Sex(male/female)

72/28

26/10

48/16

0.761

Age median (yr)

76 (66–91)

74 (66–88)

77 (66–91)

0.799

Duration of COPD (mo)

201 (18–350)

199 (18–328)

204 (22–350)

0.611

Duration of AECOPD (d)

8 (1–17)

6 (1–16)

9* (2–17)

0.004

ICU days median (d)

12 (3–28)

11 (3–28)

13 (5–28)

0.073

FEV1 (%predicted)

40 (24–66)

43 (28–66)

38 (24–64)

0.224

FVC (% predicted)

71 (47–85)

74 (49–85)

68 (47–81)

0.218

FEV1/FVC ratio (%)

45 (28–63)

48 (30–63)

43 (28–60)

0.418

PH

7.37 (7.21-7.52)

7.40 (7.21-7.49)

7.36 (7.21-7.52)

0.781

PaO2 (mm Hg)

63 (54–88)

66 (57–88)

62 (54–84)

0.556

PaCO2 (mm Hg)

65 (38–88)

68 (42–84)

63 (38–88)

0.218

Severity of COPD

    

GOLD stage II (moderate), n (%)

14(14%)

12(33.33%)

2(3.13%)

< 0.001

GOLD stage III (severe), n (%)

60(60%)

20(55.56%)

40(62.5%)

< 0.001

GOLD stage IV (very severe), n (%)

26(26%)

4(11.11%)

22(34.37%)

< 0.001

APACHE-II score

24 (18–38)

22 (18–37)

25** (19–38)

0.001

SAPS II score

40 (22–62)

38 (22–60)

42** (24–70)

0.001

BMI (m2/kg)

20.7 (17.2-26.4)

20.9 (18.3-26.0)

20.6 (17.2-26.4)

0.072

Caloric intake (kcal/d)

1274 (922–1689)

1418 (1220–1689)

1100** (922–1425)

0.001

SIRS, n (%)

71(71%)

20(55.56%)

48(75%)*

0.045

Sepsis, n (%)

54(54%)

12(33.33%)

42(65.63%)**

0.002

White blood cells (109/L)

12.3 (1.8-32.2)

12.5 (2.0-30.6)

12.2 (1.8-32.2)

0.073

BNP (pg/ml)

546 (176–1208)

455 (176–1010)

557 (221–1208)

0.069

Total bilirubin (μmol/L)

22.5 (4.2-55.7)

21.7

23.5* (5.4-55.7)

0.047

(4.2-43.4)

Serum albumin (g/L)

3.1 (2.2-4.4)

3.2 (2.6–4.4)

3.0 (2.2–3.8)

0.173

Serum creatinine (mg/dl)

1.3 (0.5–3.2)

1.2 (0.6–3.1)

1.3 (0.5–3.2)

0.279

Lactic acid (mmol/L)

2.2 (0.8-5.3)

2.1 (0.8-4.7)

2.3* (0.8-5.3)

0.038

C-reactive protein (mg/dl)

49 (15–229)

52 (34–203)

48 (15–229)

0.066

Procalcitonin (μg/L)

2.8 (0.5-15.7)

2.7 (0.5-12.4)

2.9 (1.7-15.7)

0.051

RBP-4 (mg/L)

59.7 (21.3-128.6)

74.2 (32.6-128.6)

51.5** (21.3-84.2)

0.001

  1. ICU, intensive care unit; FEV1, 1-second forced expiratory volume; FVC, forced vital capacity; APACHE, acute physiology and chronic health evaluation; SAPS, simplified acute physiology score; BMI, body mass index; SIRS, systemic inflammatory response syndrome; BNP, B-type natriuretic peptide; RBP4, Retinol-binding protein-4. Compared with Survivors, *p < 0.05, **p < 0.01.
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Journal of Inflammation

ISSN: 1476-9255

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