HIF-1α KO mice have reduced response to LPS in vivo. A Neutrophil recruitment to the site of LPS injection as determined by MPO assay. B H&E stained section of mouse skin injected with LPS, 24 h post-injection in low and high power magnification. Scale bars = 50 µm. C Amount of mVEGF, mIL-6, and KC in mouse skin, 24 h post-injection with LPS. * indicates P < 0.05.