Figure 1

AKB-4924 boosts production of VEGF, IL-6 and IL-8 by HaCat keratinocytes in vitro. A Cytokine production in control cells after the addition of vehicle (black bars) or after the addition of 10 μM AKB-4924 (white bars). B Cytokine production under normoxia (black bars), hypoxia (white bars), or hypoxia with AKB-4924 (gray bars). C Cytokine production in control cells (black bars), cells stimulated with LPS (white bars), or cells treated with LPS in conjunction with AKB-4924 (gray bars). D Cytokine production by cells under hypoxia alone (black bars), LPS stimulation under hypoxia (white bars), or LPS stimulation in conjunction with AKB-4924 under hypoxia (gray bars). For all panels, * indicates P < 0.05, ** indicates P < 0.01, *** indicates P < 0.001 as determined by student’s t-test or one-way ANOVA.