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Figure 6 | Journal of Inflammation

Figure 6

From: A hexadecylamide derivative of hyaluronan (HYMOVIS®) has superior beneficial effects on human osteoarthritic chondrocytes and synoviocytes than unmodified hyaluronan

Figure 6

Effect of HA on HSF phosphoproteins. A) Time course (minutes) of the appearance of phosphorylated p38 (black markers, dashed line) and JNK (white markers, solid line) in HSF after the addition of IL-1β. B)F) Dose response of the effect on levels of the indicated signalling proteins of the hexadecylamide derivative of HA added one hour before (white markers, solid line) or simultaneously with (black markers, dashed line) of IL-1β (2 ng/mL) to cultures of HSF. Cultures were harvested after 30 minutes with IL-1β corresponding to peak levels (A). P < 0.05 for differences from cultures with IL-1β alone (no added HA; #) or differences +/− pre-incubation (§). Values are mean % change from IL-1 alone in cells from five separate patients.

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