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Figure 1 | Journal of Inflammation

Figure 1

From: TRPM2 channels are not required for acute airway inflammation in OVA-induced severe allergic asthma in mice

Figure 1

Airway resistance and mucus production are not affected in TRPM2-/-mice. A) General priming and challenge scheme for the experimental allergic model used in all investigations (see Methods for details). B) Airway resistance to increasing concentrations of intravenously administered acetylcholine in WT (black symbols) and TRPM2-/- (red symbols) mice challenged with OVA and saline. Values represent means ± SEM (n = 10) from 2 experiments with 5 mice per group. ACh concentrations of 3 μM or higher produced significantly higher resistance in OVA-treated mice compared to saline-treated, but no significance differences were observed between WT and TRPM2-/- mice. C) PAS staining of lungs from WT (left panels) or TRPM2-/- mice (right panels) challenged with saline (top panels) or OVA (bottom panels). Images are representative of 10 mice per group. Relevant areas of normal and inflamed tissue with mucus-producing goblet cells are marked by a square and shown as enlarged insets in each graph (aw = airway).

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