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Table 2 Percent inhibition or stimulation of Salmonella -induced IL8 and NFKBIA mRNA expression

From: Transcription networks responsible for early regulation of Salmonella-induced inflammation in the jejunum of pigs

Chemical Key factor genes (3 listed) CAS # chemical group   NFKBIA IL8
    μM % % % %
    hours 4 20 4 20
Genistein FOS 446-72-0 0.5 80 57 18 54
CEBPB & D Isoflavones 5 71 56 12 66
PITX2   50 53 27 3 11
Quercetin IL1B 117-39-5 2 92 61 86 90
NFKBIA Flavonols 20 111 75 86 92
F3   200 241 52 19 26
Indomethacin EGR1 53-86-1 1 106 66 86 93
NR4A1 Indoles 10 123 129 86 101
NFKBIA   100 261 108 19 42
    hours 3 6 3 6
Curcumin ETS2 458-37-7 1 186 111 275 138
CEBPB Diarylheptanoids 10 412 100 843 37
NFE2L2   100 27 10 86 24
Chenodeoxycholic Acid PPARG 474-25-9 1 217 145 291 317
NR4A1 Bile Acids and Salts 10 407 140 468 293
XBP1   100 591 211 779 318
Nordihydroguaiaretic Acid HSD11B2 500-38-9 1 226 118 141 85
FOS Lignans 10 222 78 214 123
IL8   100 15 6 2 1
(E)-Guggulsterone NFKBIA 6439929 1 135 45 77 308
NFE2L2 Plant Gums 5 96 32 69 139
STAT3   50 21 8 21 13
(Z)-Guggulsterone NFKBIA 6450278 1 75 43 23 176
NFE2L2 Plant Gums 5 46 35 18 122
STAT3   50 47 16 10 4
Sodium Selenite JUNB 10102-18-8 10 83 31 96 44
FOS Selenium Compounds 100 100 37 115 37
  PITX2   1000 143 53 30 12
  1. IL8 and NFKBIA mRNA expression was measured with QRT-PCR in IPEC-J2 cells in the absence or presence of different concentration of chemicals (μM), after 4 and 20 hours (top panel) or after 3 and 6 hours (bottom panel) of incubation. Chemicals were selected based on their association with the in this study identified key transcription factor/regulators genes (maximal 3 genes were listed per chemical). For each chemical CAS numbers (#) and the group of chemicals to which they belong were listed.